Fri Sep 16 2022

34 articles - From Friday Sep 09 2022 to Friday Sep 16 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Peritoneal Dialysis-Associated Peritonitis Trends Using Medicare Claims Data, 2013-2017.

PD-associated peritonitis rates decline over time and were lower among older patients. A claims-based approach offers a promising framework for the study of PD-associated peritonitis.

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Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.

Plasma sTNFR1 and sTNFR2 measured 3 months after discharge were independently associated with clinical events, regardless of AKI status during the index admission. sTNFR1 and sTNFR2 may assist with the risk stratification of patients during follow-up.

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Clin J Am Soc Nephrol

Implementation and Effectiveness of a Learning Collaborative to Improve Palliative Care for Seriously Ill Hemodialysis Patients.

A learning collaborative for hemodialysis centers spanning the coronavirus disease 2019 pandemic was associated with adoption of serious illness screening and goals of care discussions as well as improved documentation of advance care planning for seriously ill patients. Clinical trial registry name and registration number Pathways Project Kidney Supportive Care, NCT04125537.

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Indications for and Timing of Initiation of KRT.

We also suggest future research to differentiate patients who benefit from timely initiation of KRT from those with imminent recovery of kidney function. Until then, efforts are needed to optimize the initiation and delivery of KRT in routine clinical practice, to minimize nonessential variation, and to ensure that patients with persistent AKI or progressive organ failure affected by AKI receive KRT in a timely manner.

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J Am Soc Nephrol

Secular Changes in Mortality and Hospitalization over Time in People with Kidney Failure or Severe CKD as Compared with Other Noncommunicable Diseases.

We observed secular reductions in mortality and annual hospital days at 1 year and 5 years among incident patients with KF-RRT and severe CKD, as well as several other common noncommunicable diseases.

Pubmed   Journal   ReadQx   PMC

Kidney Int

E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation.

Thus, our results demonstrate that EP3 deficiency especially that on myeloid cells, ameliorates ischemic AKI via curbing inflammation and breaking the auto-amplification loop of necroinflammation. Hence, EP3 may be a promising target for the prevention and/or treatment of AKI.

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Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis.

Interestingly, we found that the human kidney-derived hematopoietic stem cells took up long-term residence in the recipient's bone marrow and gradually replaced their host counterparts, leading to blood type conversion and full donor chimerism of both lymphoid and myeloid lineages. Thus, our findings highlight the existence of human kidney-derived hematopoietic stem cells with a self-renewal ability able to support multilineage hematopoiesis.

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In vitro and In vivo evidence that the switch from calcineurin to mTOR-inhibitors may be a strategy for immunosuppression in Epstein-Barr-Virus-associated post-transplant lymphoproliferative disorder.

Overall, our study provides a basis for the clinical decision for the modification and reduction of immunosuppression and adds information to the complex balance of maintaining anti-viral immunity while preventing acute rejection. Thus, an immunosuppressive regime based on mTOR-inhibition and reduced or withdrawn calcineurin inhibitors could be a promising strategy for patients with increased risk of or manifested EBV-associated post-transplant lymphoproliferative disorder.

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Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased.

Patients with glomerulonephritis manifesting within four weeks after vaccination did not differ clinically from those manifesting temporally unrelated to vaccination. Thus, vaccination against SARS-CoV-2 was not associated with new-onset glomerulonephritis in these two complementary studies with most temporal associations between SARS-CoV-2 vaccination and glomerulonephritis likely coincidental.

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Particulate matter of air pollution may increase risk of kidney failure in IgA nephropathy.

The associations were robust when the time period, risk factors of cardiovascular diseases or city size were further adjusted on the basis of the above model. Thus, our results suggest PM2.5 is an independent risk factor for kidney failure in patients with IgAN but these findings will require validation in more diverse populations and other geographic regions.

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Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.

Thus, our results demonstrated mtDNA release induced by PGAM5-mediated Bax dephosphorylation and the activation of cGAS-STING pathway as critical determinants of inflammation and kidney injury. Hence, targeting this axis may be useful for treating AKI.

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The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease.

By deconvolution analysis of RNAseq samples and by immunostaining of biopsies from patients with DKD, we further confirmed a differential expression of select genes in specific macrophage subsets essentially recapitulating the studies in mice. Thus, our study provides a comprehensive analysis of macrophage transcriptomic profiles in early DKD that underscores the dynamic macrophage phenotypes in disease progression.

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Nephrol Dial Transplant

Coronary artery calcium and risk of chronic kidney disease in young and middle-aged adults.

Methods A cohort study of 113 171 Korean adults (mean age, 40.6 years) without CKD and proteinuria at baseline, who underwent a cardiac tomography estimation of CACS during health screening examinations, was performed (median follow-up: 4.2 years). The outcome was CKD, defined as an estimated glomerular filtration rate (eGFR) 0 appear to have an increased risk of CKD and may benefit from preventive measures to reduce CKD risk.

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Development and validation of a diagnostic nomogram for sarcopenia in Chinese hemodialysis patients.

The nomogram had a good diagnostic capability for sarcopenia in patients on hemodialysis and may be a convenient tool for clinical use.

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Effect of the phosphate binder sucroferric oxyhydroxide in dialysis patients on endogenous calciprotein particles, inflammation, and vascular cells.

High-dose SO reduced endogenous CPP formation in dialysis patients and yielded serum with attenuated pro-calcific and inflammatory effects in vitro.

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Factors associated with dropout from an intradialytic exercise program among patients undergoing maintenance hemodialysis.

Walking capacity, age, inflammation, and hemodialysis volume were determinants of dropout from the exercise program. Our findings provide new and important insights into the potential risk factors for dropout from long-term intradialytic exercise programs in patients undergoing hemodialysis.

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Identification of a serum and urine extracellular vesicle signature predicting renal outcome after kidney transplant.

An EV-based signature, reflecting the cardiovascular profile of the recipient, and the repairing/regenerative features of the graft, could be introduced as a non-invasive tool for a tailored management of follow-up of patients undergoing kidney transplant.

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Impact of a continuous quality improvement program on contrast-induced nephropathy in outpatients with chronic kidney disease: an interrupted time-series study.

The multifaceted approach in the CIN-QI program may be associated with the decreased incidence of CIN and increased rates of prophylactic hydration and follow-up kidney function testing.

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Impact of previous REnal TRansplantation on the mid-term renal Outcome after CARdiac surgery: the RETROCAR trial.

Patients with a functional renal allograft have a low 1-year renal allograft survival rate after cardiac surgery with CPB. In addition, these patients have significant risks of AKI and acute kidney disease after open-heart surgery.

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Intravenous Glu-plasminogen attenuates cholesterol crystal embolism-induced thrombotic angiopathy, acute kidney injury and kidney infarction.

These results provide the first experimental evidence that Glu-plasminogen could be an innovative therapeutic strategy to attenuate thrombotic angiopathy, AKI, kidney necrosis, and potentially other clinical manifestations of CC embolism syndrome.

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Pretransplant evaluation and the risk of glucose metabolic alterations after renal transplantation: a prospective study.

PreDM or PTDM develops in waitlisted patients with an ineffective insulin secretion and BMI shows a similar diagnostic capacity to OGTT. Pretransplant interventions may reduce post-transplant glucose alterations.

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Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects.

Sequential therapy with RTX effectively reduces relapses in patients with difficult-to-treat steroid- and/or CNI-dependent or CNI-refractory nephrotic syndrome. Therapy is associated with high rates of hypogammaglobulinemia and infusion reactions.

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Two-step screening for depressive symptoms in patients treated with kidney replacement therapies - cross-sectional analysis.

A 2-step screening using PHQ-2 =1 followed by PROMIS-D =53 has good sensitivity and specificity for identifying potentially significant depressive symptoms among patients on kidney replacement therapies. This approach has lower question burden. Screened-in patients will need further clinical assessment to establish diagnosis.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Race, Ancestry, and Genetic Risk for Kidney Failure.

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Clin J Am Soc Nephrol

Palliative Care for Hemodialysis Patients?

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J Am Soc Nephrol

Concurrent Hospice and Dialysis: Proof of Concept.

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Sex Disparities in the Quality of Care for CKD.

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Nat Rev Nephrol

Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease.

However, major clinical guidelines are not consistent in their incorporation of CKD measures for CVD risk prediction. Mitigating CVD risk in patients with CKD effectively requires multidisciplinary care that involves nephrologists, cardiologists and other health professionals, as well as further work to address current research and implementation gaps.

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Regulation of nephron progenitor cell lifespan and nephron endowment.

In humans, a tenfold variation in nephron endowment between individuals contributes to differences in susceptibility to kidney disease; however, the mechanisms underlying this variation are not yet clear. Salient advances in our understanding of environmental inputs, and of intrinsic molecular mechanisms that contribute to the regulation of cessation timing or nephron progenitor cell exhaustion, have the potential to inform interventions to enhance nephron endowment and improve lifelong kidney health for susceptible individuals.

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Nephrol Dial Transplant

Dendrin in IgA nephropathy: protective or marker of early disease?

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Starting chronic hemodialysis twice-weekly: when less is more.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Kidney Int

COVID-19 vaccine effectiveness in patients with non-dialysis dependent chronic kidney diseases; findings from a population based observational study from British Columbia, Canada.

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Traditional indigenous medicines are an etiologic consideration for NELL1-positive membranous nephropathy.

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Nephrol Dial Transplant

Plasma exchange or immunoadsorption for recurrent focal segmental glomerulosclerosis: clear differences in vitro.

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Letters&Replies

Letters to the editors and authors’ replies